Gut Microbiome and Colorectal Cancer

Heliopolis University

Status

Completed

Conditions

Colorectal Cancer

Treatments

Other: no intervention

Study type

Observational

Funder types

Other

Identifiers

NCT06748339

HU.REC.H10-2024

Details and patient eligibility

About

Colorectal cancer (CRC) is reported to be the third leading cause of cancer deaths worldwide, and its prevalence is steadily rising in developing countries. It can be considered a marker of socioeconomic development and a marker of significant changes in food habits and lifestyle. In Egypt, CRC represents the seventh most common cancer. It is the third most reported cancer in males and the fifth most common cancer in females. microbiome dysbiosis may be involved in the pathogensis and thus pose a therapeutic target

Full description

Many reports suggested the role of westernized dietary lifestyles, including high consumption of red meats, animal fats, and cholesterol-rich foods, as well as smoking, decreased physical activity, obesity, diabetes, alcohol consumption, or smoking, in CRC development. These changes in lifestyle are called the external factors, which are now linked to changes in the inner gut microenvironments, mainly the microbiomes. Our aim is to investigate the the changes in microbiome profile in relation to clinical, pathological and lifestyle factors

Enrollment

18 patients

Sex

All

Ages

40 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age of 40 years to 80 years
Patients with a newly diagnosed CRC

Exclusion criteria

Patients with previously known CRC
Pregnancy or Lactation
Abdominal surgery within/up to 6 months prior to sample collection
Antibiotics, corticosteroids, or probiotics up to three months prior to sample collection
History of other types of cancer
Subjects on a special diet
Diabetes, liver, or kidney diseases
CRC patients who used enema or underwent colonoscopy up to one week before sample collection.