Gut Microbiome Associated Study of Shanghai Infants With Jaundice

Tongji University

Status: Unknown

Conditions: Gastrointestinal Microbiome

Treatments: Dietary Supplement: Probiotics

Study type: Interventional

Funder types: Other

Identifiers

NCT03510936

SHSYEK2018

Details and patient eligibility

About

The purpose of this study is to evaluate the effect of probiotics on the gut microbiome of infants with jaundice.

Full description

This study aims to examin the impact of probiotics administration during the process of infants jaundice treatment and recovery phase.the recovery phase.Birth,7 days,14 days and 42 days data will be collected and put into analysis to provide some suggestions on the probiotics use in the clinical for the infants with jaundice.

Enrollment: 30 estimated patients

Sex: All

Ages: 1 hour to 28 days old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Newborns with jaundice treated with blue light phototherapy

Exclusion criteria

• Gestational weeks <37 Birth weight <2500g or ≥4000g History of asphyxia anoxia at birth With infectious diseases treated with antibiotic With congenital metabolic diseases or hereditary diseases With gastrointestinal diseases

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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30 participants in 2 patient groups

blue light phototherapy

No Intervention group

Description:

the patients in this arm will not receive probiotics.

probiotics concurrent with phototherapy

Experimental group

Description:

the patients in this arm will receive probiotics blend of Bifidobacterium longum, Lactobacillus acidophilus, Enterococcus faecalis for 2 weeks

Treatment:

Dietary Supplement: Probiotics