Gut Microbiota, Anastomotic Leak and Colorectal Cancer

Centre hospitalier de l'Université de Montréal (CHUM)

Status: Active, not recruiting

Conditions: Colorectal Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT04071964

19.021-YP,2020-8305

Details and patient eligibility

About

This is a prospective study evaluating the relation between the gut microbiota composition, intestinal healing after colorectal surgery and colorectal cancer behavior.

Our hypothesis is that the gut microbiota composition could predict poor intestinal healing in colorectal surgery, and that the gut microbiota might have an impact on colorectal cancer clinical behavior and may predict disease outcomes.

Full description

No more details required

Enrollment: 300 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18 years and older
• CRC diagnosis
• Upcoming colonic and/or rectal resection with/without anastomosis
• Individuals without diseases of the colon and rectum (healthy controls)

Exclusion criteria

• Pregnancy
• Previous stoma
• Bowel surgery in the last 4 weeks prior to the surgery

Secondary objectives, inclusion criteria are as follows:

• Age 18 years and older
• Rectal cancer diagnosis with histopathological confirmation
• Abdominoperineal resection with terminal colostomy
• Expectative non-surgical management ("Watch and wait approach")

Trial design

300 participants in 4 patient groups

Groupe 1

Description:

Patients with colorectal cancer undergoing resection with anastomosis

Groupe 2

Description:

Patients with colorectal cancer undergoing resection without anastomosis (Abdominoperineal resection)

Groupe 3

Description:

Patients with rectal cancer without surgery ("Watch and wait")

Groupe 4

Description:

Control group consisting of patients who do not have surgical pathologies of the colon and rectum