Gut Microbiota Association With ESBL-E Colonisation and Subsequent ESBL-E Infection (Microbe)

University of Bordeaux

Status: Unknown

Conditions: Extended Spectrum Beta-Lactamase Producing Bacteria Infection; Microbial Colonization; Critical Illness

Treatments: Diagnostic Test: ESBL-E fecal carriage screening according to routine care

Study type: Observational

Funder types: Other

Identifiers

NCT04131569

Microbe

Details and patient eligibility

About

Antimicrobial resistance is a major threat worldwide and extended-spectrum beta-lactamase producing Enterobacteriales (ESBL-E) are a leading cause because of their wide dissemination. Gut microbiota seems to be correlated with multi-drug resistant organism carriage. This study thus aims to analyse the correlation between gut microbiota, ESBL-E fecal carriage and subsequent infection.

Full description

The rising antimicrobial resistance has led to more than 33,000 deaths in Europe in 2015. Among them, extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) are the most frequent in Europe and have disseminated both in the community and in healthcare settings. Some studies have suggested that microbiota could be different between multi-drug resistant organisms, with different relative abundances of some bacteria. One study focused on ESBL-E fecal carriers, but in the community, with Bacteroides uniformis being more abundant in ESBL-E non-carriers than carriers. As identification of species discriminating between ESBL-E fecal carriers and non-carriers could pave the way for the design of ESBL-E carriage eliminating probiotics, we aim to analyse the correlation between gut microbiota and ESBL-E fecal carriage.

Moreover, mechanisms in the link between ESBL-E fecal carriage and subsequent ESBL-E infection remain, so far, poorly understood and this study aims to provide a first insight in the involvement of gut microbiota in the link between colonization and infection.

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient above 18 year-old admitted to intensive care unit
• ESBL-E fecal carriage according to current screening recommendations for ESBL-E carriage group
• Feces quantity on rectal swab adequate for routine screening and microbiota analysis

Exclusion criteria

• Guardianship, curatorship, or prisoners
• No health insurance
• No legal representative

Trial design

60 participants in 2 patient groups

ESBL-E fecal carriers

Description:

Patients with a positive ESBL-E fecal carriage according to routine screening

Treatment:

Diagnostic Test: ESBL-E fecal carriage screening according to routine care

non ESBL-E fecal carriers

Description:

Patients without positive ESBL-E fecal carriage according to routine screening

Treatment:

Diagnostic Test: ESBL-E fecal carriage screening according to routine care