Gut Microbiota in Intestinal Barrier Damage in Acute Leukemia Patients Undergoing Inpatient Induction

University of Minnesota (UMN)

Status: Completed

Conditions: Acute Leukemia; Chemotherapy-Induced Gut Barrier Damage

Treatments: Diagnostic Test: Observational: Blood Sample Collection; Diagnostic Test: Observational: Stool Sample Collection; Diagnostic Test: Observational: Urine Sample Collection

Study type: Observational

Funder types: Other

Identifiers

NCT03316456

HM2017-21 (Other Identifier)

2017NTLS052

Details and patient eligibility

About

This is an observational study to collect stool, blood, and urine from acute leukemia patients undergoing induction chemotherapy in order to generate preliminary data regarding the association between microbiota and chemotherapy-induced gut barrier damage. This study consists of inpatient collections of blood, urine, and stool while the patients are undergoing inpatient induction therapy. Patients will not be scheduled for any additional procedures or testing beyond what is required for clinical care.

Enrollment: 20 patients

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Adults (ages 18 - 99 years) undergoing inpatient induction chemotherapy for newly diagnosed or relapsed acute leukemia (myeloid or lymphoblastic).
• Any induction regimen (standard or experimental) with planned ~4 weeks of inpatient stay
• Able to provide written voluntary consent before performance of any study related procedure.

Trial design

20 participants in 1 patient group

AL Patients Undergoing Induction Chemotherapy

Description:

Adults undergoing inpatient induction chemotherapy for newly diagnosed/relapsed acute leukemia.

Treatment:

Diagnostic Test: Observational: Blood Sample Collection

Diagnostic Test: Observational: Urine Sample Collection

Diagnostic Test: Observational: Stool Sample Collection