Gut Microbiota in Obesity and Diabetes

Gulhane School of Medicine

Status: Completed

Conditions: Type 2 Diabetes Mellitus; Obesity

Treatments: Other: Comparison of the gut microbiota composition

Study type: Observational

Funder types: Other

Identifiers

NCT02180191

GSM-2012/48

GSM-2012 (Other Identifier)

Details and patient eligibility

About

An altered gut microbiota composition has recently been linked to obesity and diabetes. The principal aim of this study was to investigate and compare the gut microbiota composition of obese, diabetic and control individuals. Then, associations between analyzed gut microbial concentrations and clinical-biochemical blood parameters were assessed.

Enrollment: 81 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Subjects with obesity or newly diagnosed type 2 diabetes
• 18 years to 65 years of age

Exclusion criteria

• Any chronic disease (other than obesity and diabetes)
• Alcohol consumption/smoking
• Pregnancy/breastfeeding
• The use of antibiotics, pro-prebiotics within 3 months
• <18 years or >65 years
• History of intestinal surgery

Trial design

81 participants in 3 patient groups

Obesity

Description:

27 obese individuals (20 men and 7 women with mean BMI: 39.98±5.56 kg/m2)

Treatment:

Other: Comparison of the gut microbiota composition

Diabetes

Description:

26 patients with newly diagnosed type 2 diabetes (18 men and 8 women with mean BMI: 28.63±5.08 kg/m2)

Treatment:

Other: Comparison of the gut microbiota composition

Control

Description:

Healthy control subjects (22 men and 6 women with mean BMI: 23.02±1.70 kg/m2)

Treatment:

Other: Comparison of the gut microbiota composition