Gut Microbiota Metagenomics for Chronic Liver Disease

Chuncheon Sacred Heart Hospital

Status: Active, not recruiting

Conditions: Liver Disease Chronic

Treatments: Other: DNA extraction

Study type: Observational

Funder types: Other

Identifiers

NCT04339725

STOOL

Details and patient eligibility

About

Gut microbiota modulation has effect on chronic liver disease

Full description

Chronic liver disease has been known as a disease of the liver which lasts over a period of 6-month. It consists of inflammation, hepatitis, cirrhosis, hepatocellular carcinoma.

Gut microbiota plays an important roles in the chronic liver disease. It can suppress the progression of the liver disease by moulation gut microbiota.

The investigators are still evaluating the effect of gut microbiota on the liver disease.

Enrollment: 3,240 patients

Sex: All

Ages: 31 to 82 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 19+
• Normal : AST or ALT level < 50IU/L, BMI < 25
• Liver disease : AST or ATL level ≥ 50IU/L, BMI ≥ 25
• Patients hospitalized with chronic liver disease (viral hepatitis, alcoholic liver disease, non-alcoholic liver disease, cirrhosis, liver cancer)

Exclusion criteria

• Normal : AST or ATL level ≥ 50IU/L, BMI ≥ 25
• Liver disease : AST or ALT level < 50IU/L, BMI < 25
• If the patient refuses

Trial design

3,240 participants in 1 patient group

Fecal DNA

Description:

Extraction fecal DNA and compare disease group to normal group

Treatment:

Other: DNA extraction