Gut Microbiota, "Spark and Flame" of COVID-19 Disease

New University of Lisbon

Status: Completed

Conditions: COVID-19

Treatments: Other: Exposure

Study type: Observational

Funder types: Other

Identifiers

NCT04355741

COVID19_Microbiota

Details and patient eligibility

About

Elderly, hypertension, diabetes and cardiovascular diseases are risk factors for COVID-19 morbility and mortality. However, the real reason for this is not yet understood. It is well documented that gut microbiota has a critical role in health, particularly in the immune system and therefore, we propose that gut microbiota composition could affect vulnerability and disease outcomes of COVID-19.

Full description

In order to explore this hypothesis, we will analyse the gut microbiota of SARSCoV-2 infected patients categorized according to location: [1] ambulatory (self-isolation at home), [2] ward and [1] ICU; and severity.

Enrollment: 115 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults of 18 years and above.
• COVID-19 patients.

Exclusion criteria

• None.

Trial design

115 participants in 3 patient groups

Ambulatory

Description:

Patients that are self-isolated at home

Treatment:

Other: Exposure

Ward

Description:

Patients that are in an isolated room at the hospital

Treatment:

Other: Exposure

ICU

Description:

Patients that are in the ICU of the hospital

Treatment:

Other: Exposure