Gut Mucosal Microbiota is Associated With Colorectal Cancer Relapse

Harbin Medical University

Status

Unknown

Conditions

Gut Microbiota

Colorectal Cancer

Study type

Observational

Funder types

Other

Identifiers

NCT03385213

Yunwei Wei 2017 -2

Details and patient eligibility

About

Colonic microbiome has been found to contribute to the development of colorectal cancer. We speculate that gut microbiota related to colorectal cancer relapse after curative treatment. This study aim to discover if any difference of gut microbiota exist in patients who suffer from cancer relapse compared with patients who do not. Finally develop patient-centred programmes of surveillance protocols base on microbiota analysis.

Full description

Treatments for colorectal cancer of all stages have evolved considerably over the past two decades, resulting in improved long-term outcomes. After curative treatment, however, 30% of patients with stage I-III and up to 65% of patients with stage IV colorectal cancer develop recurrent disease.

The human colon plays host to a diverse and metabolically complex community of microorganisms. While the colonic microbiome has been found to contribute to the development of colorectal cancer. Investigators speculate that gut microbiota related to colorectal cancer relapse after curative treatment.

Patients are routinely offered surveillance in order to detect disease recurrence at an early, asymptomatic stage, with the intention of improving survival. Nevertheless, controversy continues to surround the optimal surveillance protocols. Investigators aim to discover if any difference of gut microbiota is exist in patients who suffer from relapse compared with patients who do not.

Future surveillance after colorectal cancer treatment should focus on risk-stratification and should incorporate current knowledge on risk of recurrence in relation to the biology of the tumour as well as gut microbiota feature. Finally investigators will develop patient-centred programmes of surveillance protocols base on microbiota analysis.

Enrollment

200 estimated patients

Sex

All

Ages

35 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Requirements of informed consent and assent of participant, parent or legal guardian as applicable
Patients with colorectal cancer scheduled for radical coloproctectomy and between the age of 18 and 75 years old without considering sex.
Patients with BMI= 18.5-23.9
Participants can follow the visit plan

Exclusion criteria

Patients with colorectal cancer with distant metastasis
Chronic renal diseases and hepatic cirrhosis
Chronic ischemic heart disease with unstable angina, chronic heart failure at class III or IV and acute myocardial infarction in the last 6 months
Individuals with a history of Chronic diarrhea
Individuals with a history of Diabetes mellitus
Individuals with a history of Hypertension
Individuals with a history of autoimmune diseases
Use of antibiotics and probiotics 3 mouth before samples collection
Individuals with a history of abdominal operation due to any reason
Individuals with any history of cancer other than colorectal cancer
Individuals with Inflammatory bowel disease