Gut Permeability Assessment in Celiac and Gluten Sensitive Children

Mayo Clinic

Status: Completed

Conditions: Celiac Disease

Study type: Observational

Funder types: Other

Identifiers

NCT02690532

15-006018

Details and patient eligibility

About

This study will assess the effect of gluten on gut barrier function. Investigators at the Mayo Clinic have developed a new gut permeability test using rhamnose (sugar & water solution), and are hoping to prove its effectiveness in a clinical setting.

Full description

The aim of this study is to assess effect of gluten on the gut barrier function in patients at high risk for celiac disease and non-celiac gluten sensitivity (NCGS) patients. This study will assess the gut permeability in three groups of patients 1) children who are at high risk for developing celiac disease (CD) (siblings of patients with celiac disease), 2) Children who are self-diagnosed with NCGS and 3) control group of patients matched for age and gender. Patients will undergo celiac serologic and genetic testing, after which the rhamnose test will be performed to assess the presence of increased gut permeability.

Enrollment: 40 patients

Sex: All

Ages: 2 to 17 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

High Risk group:

• Sibling with a confirmed diagnosis of celiac disease
• No history Celiac disease or any other bowel disease

Non-Celiac Gluten Sensitivity group:

• Self-diagnosis of gluten sensitivity
• No history of celiac disease or other bowel disease

Healthy group:

• Absence of celiac disease or any other bowel disease
• No sensitivity to gluten

Trial design

40 participants in 3 patient groups

High risk group

Description:

Children who are at high risk for developing celiac disease (siblings diagnosed with celiac disease).

Non-celiac group

Description:

Children who are self-diagnosed with non-celiac gluten sensitivity.

Control Group

Description:

Healthy control group (matched for age and gender).