Haemochromatosis and Periodontitis (HEMOPARO)

Rennes University Hospital

Status

Completed

Conditions

to Evaluate the Prevalence of Periodontal Diseases in Patients With Hemochromatosis at the Time of Diagnosis and / or Their Usual Therapeutic

Treatments

Diagnostic Test: dental probes

Study type

Interventional

Funder types

Other

Identifiers

NCT04006249

2009-A00998-49

Details and patient eligibility

About

Periodontitis is a chronic inflammatory disease that affects tissues surrounding the teeth. It is strongly associated with the major pathogenic "red complex", including Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola1 and thus is considered an infection. Recent advances in the pathogenesis of periodontal disease have suggested that polymicrobial synergy and microbiota dysbiosis together with a dysregulated immune response can induce inflammation-mediated damage in periodontal tissues2-4. Interestingly, currently periodontitis is associated with a growing number of systemic diseases, including cardiovascular diseases, adverse pregnancy outcomes, diabetes5-7 and hereditary haemochromatosis8.

Enrollment

87 patients

Sex

All

Ages

35 to 64 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients aged 35 to 64 years with homozygosity hemochromatosis C282Y
Patients regularly enrolled in a health insurance plan
Patients with at least 10 natural teeth
Patients who have given informed written, dated and signed consent

Exclusion criteria

Diabetic patients
Simultaneous participation in another study
Pregnant or lactating women
The incapacitated persons and persons deprived of their liberty
Patients who do not speak French, both written and spoken
Patients previously included in this trial
Patients with heart valves or endovascular equipment (risk of infective endocarditis ...)
Patients with a history of maxillofacial surgery
Patients whose oral status is considered incompatible with entry into the study, at the discretion of the investigator
Patients on drugs that can cause gingival hypertrophy, such as Hydantoins (phenytoin), Dihydropyridines, Diltiazem or Ciclosporin
Patients on medication that can cause gingival bleeding (anticoagulants, antiplatelet agents and aspirin).