Haemodynamic Stability of Ketamine/Propofol Admixture "Ketofol" in Patient Undergoing Endoscopic Retrograde Cholangio Pancreatography (Assiutu)

Assiut University

Status and phase: Terminated; Phase 2

Conditions: Cholangitis; Pancreatitis

Treatments: Drug: Ketamine / Propofol Admixture; Drug: Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT02618668

Momen01098983009

Details and patient eligibility

About

The investigators aim to evaluate the effect of Ketamine/Propofol Admixture on hemodynamic stability, recovery time ,patient & doctor satisfaction scores during Endoscopic Retrograde Cholangiopancreatography.

Enrollment: 90 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists ( I ,II )

Exclusion criteria

1. Presence of liver and/or kidney failure, neuropsychiatric disorders, morbid obesity.
2. History of substance abuse or dependence.
3. History of serious adverse effects related to anesthetics (e.g. allergic reactions), a family history of reactions to the study drugs.
4. Pregnancy.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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90 participants in 2 patient groups

Ketamine / Propofol Admixture

Experimental group

Description:

Ketamine / Propofol Admixture: I.V propofol-ketamine 3:1 mixture(%1 15 ml propofol + 1 ml 50mg/ml ketamine+ 4 ml saline in a 20-ml syringe which resulted in 0.25 mg.ml-1 ketamine and 0.75 mg.ml-1 propofol.

Treatment:

Drug: Ketamine / Propofol Admixture

Propofol

Active Comparator group

Description:

I.V propofol 2 mg/kg

Treatment:

Drug: Propofol