ClinicalTrials.Veeva

Menu

Hair Transplantation in Cicatricial Alopecia

A

Alexandria University

Status

Completed

Conditions

Cicatricial Alopecia
Hair Transplantation

Treatments

Procedure: follicular unit extarcation and platelet rich plasma

Study type

Interventional

Funder types

Other

Identifiers

NCT04472715
00007555

Details and patient eligibility

About

follicular unit extraction as a method of hair transplantation in cicatricial alopecia

Full description

The study will include 20 patients with cicatrical alopecia.Patients will be randomly assigned into two groups:Group (A):include ten patients will undergo (FUE) alone.

Group (B): include ten patients will undergo(FUE) and (PRP).3-Surgical technique:

  • Preoperative Investigations including complete blood count, coagulation profile and hepatitis viral markers.

    1-Group(A): will undergo (FUE)

  • Washing the scalp with antiseptic shampoo before the procedure.

  • Tumuscentanaesthesia:The donor area is anesthetized with a lidocaine 1% solution diluted with 20 cc saline in addition to adrenaline.

  • Creation of micropunches(0.7-1 mm) using micromotor.

  • After removal of the punch,the follicular unit is extracted with Jweler's forceps.

  • Extracted grafts are then placed on chilled saline gauze for maximum four hours until ready for transplantation.

  • The recipient area is prepared with rectangular scalpel blades 1mm or hypodermic blades 0.9 mm.

  • Implantation using fine tipped jweler's forceps.

  • Finally, receptor and donor areas will be softly cleansed with saline and crepe bandage is applied.

    2-Group (B): FUE+PRP

  • The same procedure will be done but grafts will be placed in Prp solution.

  • Prp session one week before transplantation then monthly for 3 monthes after (FUE).

  • Preparation of PRP

  • 10 cc blood will be aspirated in test tube contained a modified solution of anticoagulant,called acid-citrate-dextrose type (ACDA), in which the physiological pH will reached to preserve the platelet integrity.

  • The first spin of whole blood sample will be at 2500 rpm for 4 minutes

  • The second spin at 4000 for 20 minutes for obtained plasma.

  • Platelets are separated as a pellet at the bottom of the tube from platelet-poor plasma (PPP) above. The platelet-rich pellet is resuspended in remaining amount of plasma. The resulting suspension is used as PRP.

  • Prp is injected in the recipient area. 4-Follow up:

  • Follow up clinically by digital photographs and trichoscopy 1 week after operation, after 3 months and after 6 months.

Enrollment

20 patients

Sex

All

Ages

18 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • • Patients with unacceptable visible scarring alopecia.

    • Adequate donor area.
    • patient free of signs of disease activity evidenced by trichoscopy.
    • Patients having inadequate laxity for a strip excision (too tight skin).
    • When previous scars of strip surgeries make further strips impossible.

Exclusion criteria

  • • Inadequate donor area.

    • Signs of active disease or infection.
    • Patient who is not willing for long sessions for several hours or multiple sessions as needed due to the slowness of the process
    • Contraindications for surgical procedure as bleeding tendency.
    • Contraindications for PRP as (cardiovascular, autoimmune disorders, hematological disorders and neoplasms).

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Single Group Assignment

Masking

Single Blind

20 participants in 2 patient groups

follicular unit extraction
Experimental group
Description:
extraction of hair follicle unit from donar area and tranplant it into recepient bald area
Treatment:
Procedure: follicular unit extarcation and platelet rich plasma
foolicular unit extraction and platelet rich plasma
Experimental group
Description:
the same procedure mentioned above coupled with session of platelet rich plasma before and after transplantation
Treatment:
Procedure: follicular unit extarcation and platelet rich plasma

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems