Hand Function Impairment in Systemic Sclerosis: Outcomes, Mechanisms and Experience (HANDSOME)

UMC Utrecht

Status: Enrolling

Conditions: Systemic Sclerosis

Treatments: Diagnostic Test: Imaging, blood samples, fuctional tests and physical examination

Study type: Observational

Funder types: Other

Identifiers

NCT06133244

NL85445.041.23

Details and patient eligibility

About

Almost 90% of systemic sclerosis (SSc) patients experience hand function limitation, which leads to impaired daily functioning and work participation. An important cause of impaired hand function are contractures of the hand, which are reported in up to a half of patients. With this longitudinal cohort study in patients with SSc and VEDOSS (very early diagnosis of systemic sclerosis) the investigators aim to gain more insight into processes involved in hand function impairment.

Enrollment: 300 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18 years

Exclusion criteria

• Patients with diabetic cheiroarthropathy and Dupuytren's disease, based on expert opinion

Trial design

300 participants in 3 patient groups

VEDOSS

Description:

defined as RP, presence of SSc specific autoantibodies (ACA, ATA, ARA), puffy fingers and abnormal nailfold capillaroscopy (giant capillaries or capillary loss with or without haemorrhages), but not fulfilling the EULAR-ACR 2013 classification criteria for SSc

Treatment:

Diagnostic Test: Imaging, blood samples, fuctional tests and physical examination

SSc with disease duration of < 4 years without hand contractures

Treatment:

Diagnostic Test: Imaging, blood samples, fuctional tests and physical examination

SSc with hand contractures

Treatment:

Diagnostic Test: Imaging, blood samples, fuctional tests and physical examination