Hand Grip Strength and Prognosis in Hospitalized Cancer Patients (PRO-HAND)

Ankara Etlik City Hospital

Status: Completed

Conditions: Cancer; Sarcopenia; Hospitalizations; Cachexia; Cancer; Sarcopenia

Treatments: Other: Hand Grip Strength Measurement

Study type: Observational

Funder types: Other

Identifiers

NCT07167082

AEŞH-BADEK-2024-1105 (Other Identifier)

Details and patient eligibility

About

This prospective cohort study aims to investigate the relationship between hand grip strength and prognosis in hospitalized cancer patients. Hand grip strength, a simple, rapid, and non-invasive measure of overall muscle function, is increasingly recognized as an indicator of frailty, nutritional status, and physical health. The study will evaluate whether lower hand grip strength is associated with higher short-term mortality (30-day all-cause mortality) and adverse clinical outcomes, including ICU admission, hospital readmission, and functional decline.

Full description

Hand grip strength declines with age and is associated with frailty, sarcopenia, and cancer cachexia. It is a reliable prognostic marker in cancer patients. In this prospective cohort study, hospitalized patients with pathologically confirmed cancer will undergo hand grip strength measurement within the first 24 hours of admission using a calibrated hand dynamometer. Measurements will be performed on the dominant hand, with patients seated, following international standardized procedures. Three consecutive measurements will be obtained, and the average value will be recorded. Assessments will be conducted by oncology clinicians trained in the protocol. Patients will be followed for 30 days to evaluate primary and secondary endpoints, including all-cause mortality, functional decline, length of hospital stay, intensive care unit admission, readmission, and major complications.

Enrollment: 130 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults aged 18 years and older
• Pathologically confirmed diagnosis of cancer
• Hospitalized with an expected hospital stay of more than 48 hours
• Ability to provide written informed consent

Exclusion criteria

• Diagnosis of anorexia nervosa
• Acute pancreatitis or acute liver failure at admission
• History of gastric bypass surgery
• Presence of chronic active infections
• History of solid organ transplantation
• Pregnant or breastfeeding women

Trial design

130 participants in 1 patient group

Hospitalized Cancer Patients

Description:

This cohort consists of adult patients (aged 18-80 years) with pathologically confirmed cancer who are admitted to the hospital for at least 48 hours. Hand grip strength is measured within the first 24 hours of admission using a standardized dynamometer protocol. Patients are followed prospectively for 30 days to evaluate primary and secondary outcomes including all-cause mortality, functional decline, hospital stay duration, readmission, and major complications.

Treatment:

Other: Hand Grip Strength Measurement