Hannover Dialysis Outcome Study (HAND-OUT)

Hannover Medical School (MHH)

Status and phase

Completed

Phase 4

Conditions

Acute Kidney Failure

Treatments

Device: Intensified extended dialysis

Device: Standard extended dialysis

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT00529139

MHH - SLED - 01

Details and patient eligibility

About

Mortality rates of patients with acute kidney injury in the intensive care unit have changed little over the past few decades despite significant advances in supportive care. Few interventions have been shown to result in an improvement of in-hospital mortality of these patients, with dose of renal replacement therapy (RRT) being one of the most important. Patients undergoing continuous veno-venous hemofiltration had better outcomes with ultrafiltration rates of 35 mL/kg/h or 45 mL/kg/h than those treated at a rate of 20 mL/kg/h. In a different trial, intermittent hemodialysis on a daily basis resulted in better control of uremia, fewer hypotensive episodes during dialysis, and more rapid resolution of acute renal failure than thrice weekly hemodialysis. In the present study we examine survival and renal recovery in critically ill patients with acute kidney injury that are treated with a currently recommended (standard) dose of RRT, and patients that receive intensified RRT.

Enrollment

157 patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

non post-renal AKI with RRT dependency indicated by oliguria/anuria <30mL/h >6 hours prior to inclusion
loss of kidney function of >30% within 48 hours prior to inclusion
hyperkalemia >6.5 mmol/L
severe acidosis with pH<7.15

Exclusion criteria

pre-existing chronic kidney disease (CKD) as defined by an estimated glomerular filtration rate <50mL/min or a plasma creatinine concentration >1.7 mg/dL (>150 µmol/L) more than 10 days prior to initiation of the first RRT
presence of AV-fistula or dialysis catheter
participation in another study
consent denial or withdrawal
need for extra corporal membrane oxygenation therapy.