HAPH Registry: Time Course and Prognostic Significance of Pulmonary Artery Pressure in Highlanders.

University of Zurich (UZH)

Status: Not yet enrolling

Conditions: Sleep Apnea; High Altitude Pulmonary Hypertension

Study type: Observational

Funder types: Other

Identifiers

NCT06489730

HAPH_Register

Details and patient eligibility

About

The purpose of the current study is to evaluate the clinical and physiologic course of Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a longitudinal cohort study. To this end, the investigators will invite the same highlanders who participate din the study in 2017 to undergo follow-up examinations in 2024, in order to allow comparisons of current results with baseline data from 2017.

Enrollment: 120 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Permanently living >2500 m
• Written informed consent

Exclusion criteria

• Highlanders who cannot follow the study investigations,
• Patients with moderate to severe concomitant lung disease (FEV1<70% or forced vital capacity <70%), severe parenchymal lung disease, heavy smoking >20 cigarettes/day or >20 pack-years.
• Coexistent unstable systemic hypertension or coronary artery disease that required adjustment of medication within the last 2 months
• Regular use of medication that affects control of breathing (benzodiazepines, opioids, acetazolamide)

Trial design

120 participants in 2 patient groups

Highlanders living above 2500 m

Description:

Highlanders permanently living above 2500 m in the Aksay area in Kyrgyzstan

Low altitude control

Description:

Healthy lowlanders living below 1000 m.