ClinicalTrials.Veeva

Menu

Harmonic FOCUS Versus Conventional Technique in Total Thyroidectomy for Benign Thyroid Disease

E

Ethicon

Status

Completed

Conditions

Benign Thyroid Disease

Study type

Observational

Funder types

Industry

Identifiers

NCT00666315
EO-0469
CME-07-001

Details and patient eligibility

About

New haemostatic techniques have been developed with the advent of laparoscopic surgery. Among other things, ultrasound instruments have been used for the dissection, division and coagulation of vessels and other tissue. Previous studies in Thyroidectomy observed a clinically and economically significant reduction in operating time with no increase in the complication rate when the Harmonic device has been used. The aim of the present clinical trial is to evaluate potential advantages of a new Harmonic device (FOCUS), developed especially for Thyroid procedures, in the use of HS in thyroidectomies when compared with EC in terms of operative time, number of ligatures, QoL, blood loss, pain intensity at the surgical site, amount of drainage, and complications, including the incidence of RLN palsy and hypoparathyroidism.

Full description

Thyroidectomy is one of the most frequently performed operations in endocrine surgery. Results are generally excellent, and morbidity and mortality are usually negligible. The operation requires proper identification of important structures such as the recurrent laryngeal nerve (RLN) and the parathyroid glands. Meticulous dissection and exhaustive hemostasis are important to ensure a dry field and to avoid inadvertent damage to the adjacent structures. The two most common techniques for hemostasis are suture ligatures and electrocoagulation. The use of electrocoagulation (EC) to control bleeding has the potential risk of injuring the surrounding structures from lateral dispersion of heat. New haemostatic techniques have been developed with the advent of laparoscopic surgery. Among other things, ultrasound instruments have been used for the dissection, division and coagulation of vessels and other tissue. Previous studies in Thyroidectomy observed a clinically and economically significant reduction in operating time with no increase in the complication rate when the Harmonic device has been used. The aim of the present clinical trial is to evaluate potential advantages of a new Harmonic device (FOCUS), developed especially for Thyroid procedures, in the use of HS in thyroidectomies when compared with EC in terms of operative time, number of ligatures, QoL, blood loss, pain intensity at the surgical site, amount of drainage, and complications, including the incidence of RLN palsy and hypoparathyroidism.

Enrollment

80 patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Elected to undergo total thyroidectomy.
  • Able to comprehend and sign the applicable study informed consent form.
  • Able to return for all study mandated visits (visit 1 and 2)
  • Be greater than or equal to 18 years of age.

Exclusion criteria

  • Previous neck operation
  • History of neck irritation
  • Need for central or lateral compartment lymphadenectomy
  • Patients under permanent pain killer medication
  • Patients under anticoagulation medication

Trial design

80 participants in 2 patient groups

Harmonic
Description:
Group operated with Harmonic device
Conventional
Description:
Group operated with Electrocauery and Clip/Suture

Trial contacts and locations

2

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2026 Veeva Systems