hCAP18 Levels and Vitamin D Deficiency in Healthy Subjects

Mass General Brigham

Status: Completed

Conditions: Vitamin D Deficiency; Healthy Subjects

Treatments: Drug: ergocalciferol

Study type: Interventional

Funder types: Other

Identifiers

NCT00742235

2008-P-0003000/1

Details and patient eligibility

About

Vitamin D deficiency (low levels of vitamin D in the blood) is a common problem. A recently discovered protein, called hCAP18, likely plays an important role in the immune system and may depend on adequate levels of vitamin D. It is not known what levels of vitamin D are needed to allow the body to make this protein. Nor is it known if giving vitamin D to people who are found to be deficient will help boost levels of hCAP18. This study aims to clarify the relationship between vitamin D levels and hCAP18.

Enrollment: 99 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18-80

Exclusion criteria

• Known active infectious disease or chronic inflammatory disorder
• Hypercalcemia
• Chronic kidney disease
• Pregnancy

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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99 participants in 2 patient groups

1

Experimental group

Description:

Vitamin D insufficient (treated with ergocalciferol 50,000 IU every other day x 5 doses)

Treatment:

Drug: ergocalciferol

Vitamin D sufficient

No Intervention group

Description:

Subjects who did not receive ergocalciferol and had a 25-OH vitamin D level \>32 ng/ml