HCC Staging Modified by Tumor Micronecrosis

Zhejiang University

Status: Completed

Conditions: Hepatocellular Carcinoma

Treatments: Behavioral: tumor micronecrosis

Study type: Observational

Funder types: Other

Identifiers

NCT05739110

HCCNSTAGE

Details and patient eligibility

About

Tumor micronecrosis is a pathological feature that reflects malignant biological behavior in hepatocellular carcinoma (HCC). This study aimed to evaluate the prognostic significance of tumor micronecrosis based on the current BCLC and TNM staging systems, and futher improve the performance of the staging models by establishing modified new staging models including tumor micronecrosis.

Enrollment: 1,100 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• primary and histologically confirmed HCCs
• patients who underwent curative liver resection

Exclusion criteria

• simultaneous presence of other tumors
• patients who had received preoperative antitumor therapies
• no available surgical specimens for evaluating micronecrosis status
• gross tumor necrosis and Nscore = 3

Trial design

1,100 participants in 2 patient groups

micronecrosis(+) group

Description:

Hepatocellular patients with tumor micronecrosis.

Treatment:

Behavioral: tumor micronecrosis

micronecrosis(-) group

Description:

Hepatocellular patients without tumor micronecrosis.