HCG Levels After Ovulation Triggering as Predictors of ICSI Outcome

Mansoura University

Status: Completed

Conditions: Infertility

Treatments: Drug: uHCG and GnRHa; Drug: uHCG; Drug: rHCG

Study type: Observational

Funder types: Other

Identifiers

NCT05969834

MD.20.09.370

Details and patient eligibility

About

This study aimed to assess the correlation between HCG levels after ovulation triggering and ICSI outcomes, affected by HCG formulation and dose

Full description

The aims of this study are:

1. To assess the correlation between serum human chorionic gonadotropin (hCG) level after ovulation triggering and intracytoplasmic sperm injection (ICSI) outcome including: oocyte maturity and quality, good quality embryo rate, blastocyst formation rate and pregnancy rate
2. To determine if there is an association between type and dose of the trigger and ICSI outcome.

Enrollment: 100 patients

Sex: Female

Ages: 18 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women who will undergo controlled ovarian stimulation (COS) through fixed GnRH antagonist protocol

Exclusion criteria

• BMI > 30 kg/m2
• Irregular menstruation
• Severe male factor abnormality
• Poor ovarian reserve
• Endometriosis
• Uterine abnormality

Trial design

100 participants in 3 patient groups

uHCG group

Description:

Trigger intramuscular (IM) administration of 10000 IU of uHCG

Treatment:

Drug: uHCG

rHCG group

Description:

Trigger with subcutaneous (SC) administration of 6500 IU of rHCG

Treatment:

Drug: rHCG

Dual trigger group

Description:

Combined SC administration of 0.1 mg of GnRHa and IM administration of 2500 IU of uHCG

Treatment:

Drug: uHCG and GnRHa