hCG Supplementation in Frozen-Thawed Embryo Transfer Cycle

Hadassah Medical Center

Status and phase: Completed; Phase 2

Conditions: Fertility Agents, Female

Treatments: Drug: s.c. human chorionic gonadotropin (Ovitrelle)

Study type: Interventional

Funder types: Other

Identifiers

NCT00398229

freezehcg-HMO-CTIL

Details and patient eligibility

About

The implantation rate after frozen-thawed embryo transfer cycles depends mostly on the receptivity of the endometrium and the embryo quality.The effects of human chorionic gonadotropins (hCG) on the endometrium have been investigated for several years. hCG was shown to up-regulate gene expression during the differentiation of human endometrial stromal cells into decidua. The aim of our study was to assess the benefit of hCG supplementation throughout the secretory phase of artificial frozen-thawed embryo transfer cycles.

Enrollment: 300 estimated patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• all women on frozen-thawed embryo-transfer cycle

Exclusion criteria

• any allergy to injection of human chorionic gonadotropin before

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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300 participants in 2 patient groups, including a placebo group

A

Active Comparator group

Description:

receiving hCG injection

Treatment:

Drug: s.c. human chorionic gonadotropin (Ovitrelle)

B

Placebo Comparator group

Treatment:

Drug: s.c. human chorionic gonadotropin (Ovitrelle)