Head and Neck Squamous Cell Carcinoma (HNSCC)PET-CT Pilot Study

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University Health Network, Toronto

Status

Enrolling

Conditions

Head and Neck Squamous Cell Carcinoma

Treatments

Drug: 18-F FDG

Study type

Interventional

Funder types

Other

Identifiers

NCT02678884
UHN REB 12-5378-CE

Details and patient eligibility

About

The purpose of this study is to see how useful the information provided from Positron Emission Tomography (PET) scans can be in the actual planning and delivery of radiation treatment to patients who have head and neck cancers. Patients participating in this study, will have (in addition to their routine tests) a PET scan before and during their radiation treatment. Following the intervention, patients will be followed as per standard practice.

Enrollment

20 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Non-nasopharynx head and neck mucosal squamous cell carcinoma
  • Radiologically evident gross disease
  • Radiotherapy alone for curative intent
  • Age equal to or more than 18 years old
  • To be eligible for the second study PET-CT scan: FDG avid tumour (or minimum SUV of 2.5) on the first study PET-CT scan

Exclusion criteria

  • Nasopharynx cancer
  • H&N SCC skin
  • Distant metastases (already known or if found on baseline CT-thorax)
  • Prior malignancy within the last 5 years (exclude non-H&N SCC, BCC skin)
  • Prior chemotherapy within the last 5 years or concurrent chemotherapy/EGFR inhibitors
  • Prior head and neck radiotherapy
  • Inability to lie supine for study duration
  • Pregnancy
  • Inability to provide informed consent

Trial design

Primary purpose

Diagnostic

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

20 participants in 1 patient group

HNSCC Patients receiving RT
Experimental group
Treatment:
Drug: 18-F FDG

Trial contacts and locations

1

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Central trial contact

John J Kim, MD; Stephen Breen, PhD

Data sourced from clinicaltrials.gov

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