Headache Inducing Characteristics and Possible Changes in Cerebral Blood Flow After Administration of PGE2

Danish Headache Center

Status: Completed

Conditions: Migraine; Headache

Treatments: Drug: PGE2

Study type: Interventional

Funder types: Other

Identifiers

NCT00374530

KA-20060026

Details and patient eligibility

About

Before, during and after intravenous administration of PGE2 we score/measure headache, rCBF, blood flow in the middle cerebral artery and diameter of superficial temporal artery and correlate that to known pathophysiology of headache to see if PGE2 is involved in headache pathophysiology.

Enrollment: 12 estimated patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers

Exclusion criteria

• Primary Headache, headache on the day of the investigation, hypertension, hypotension, pregnant/nursing, daily intake of medication (except oral contraceptives), Cardiovascular or CNS disease, drug/alcohol abuse, psychiatric disease