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Headache Inducing Effect of Cromakalim in Migraine Patients

D

Danish Headache Center

Status

Completed

Conditions

Headache, Migraine

Treatments

Drug: Levcromakalim
Drug: Saline

Study type

Interventional

Funder types

Other

Identifiers

NCT03228355
Levcromakalim

Details and patient eligibility

About

To investigate the role of KATP channels on the cerebral hemodynamic in migraine patients.

Enrollment

16 patients

Sex

All

Ages

18 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Migraine patients of both sexes.
  • 18-60 years.
  • 50-90 kg.
  • Women of childbearing potential must use adequate contraception.

Exclusion criteria

  • Headache less than 48 hours before the tests start
  • Daily consumption of drugs of any kind other than oral contraceptives
  • Pregnant or nursing women.
  • Cardiovascular disease of any kind, including cerebrovascular diseases.

Trial design

Primary purpose

Other

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Quadruple Blind

16 participants in 2 patient groups, including a placebo group

Levcromakalim
Active Comparator group
Treatment:
Drug: Levcromakalim
Saline
Placebo Comparator group
Treatment:
Drug: Saline

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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