Headache Inducing Effect of Cromakalim in Migraine Patients

Danish Headache Center

Status: Completed

Conditions: Headache, Migraine

Treatments: Drug: Levcromakalim; Drug: Saline

Study type: Interventional

Funder types: Other

Identifiers

NCT03228355

Levcromakalim

Details and patient eligibility

About

To investigate the role of KATP channels on the cerebral hemodynamic in migraine patients.

Enrollment: 16 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Migraine patients of both sexes.
• 18-60 years.
• 50-90 kg.
• Women of childbearing potential must use adequate contraception.

Exclusion criteria

• Headache less than 48 hours before the tests start
• Daily consumption of drugs of any kind other than oral contraceptives
• Pregnant or nursing women.
• Cardiovascular disease of any kind, including cerebrovascular diseases.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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16 participants in 2 patient groups, including a placebo group

Levcromakalim

Active Comparator group

Treatment:

Drug: Levcromakalim

Saline

Placebo Comparator group

Treatment:

Drug: Saline