Healing Process and Blood Sugar Level Following Local Anesthetic Infiltration With and Without Vasoconstrictor

Minia University

Status: Completed

Conditions: Diabetes; Anesthesia, Local

Treatments: Drug: Local anaesthesia with vasocontrictor (Mepivacaine hydrochloride 20 mg (2%) + Levonordefrin hydrochloride 0.06 mg)

Study type: Interventional

Funder types: Other

Identifiers

NCT05875519

714

Details and patient eligibility

About

Evaluating the healing of the extraction socket and the glycemic levels before, and after injection of local anesthesia with and without vasoconstrictor in diabetic patients

Enrollment: 40 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Inclusion criteria patients over 20 years and under 60 years of age
• DM controlled by medication
• Requiring a tooth extraction in the maxilla, with an indication of the intra-alveolar technique for periodontal reasons.
• Only participants that are willing to control and record blood glucose level throughout the study period.

Exclusion criteria

• Patients with any significant medical condition (besides DM)
• Alcoholic individuals
• Patients on drugs that affect the central nervous systems
• Patients who reported the use of drugs that might interfere with pain sensitivity
• Pregnant and lactating women
• Patients with hypersensitivity to local anesthetics or non-steroidal anti-inflammatory drugs (NSAIDs).

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

40 participants in 2 patient groups

Anaesthesia with vasocontrictor

Experimental group

Treatment:

Drug: Local anaesthesia with vasocontrictor (Mepivacaine hydrochloride 20 mg (2%) + Levonordefrin hydrochloride 0.06 mg)

Anaesthesia without vasocontrictor

Active Comparator group

Treatment:

Drug: Local anaesthesia with vasocontrictor (Mepivacaine hydrochloride 20 mg (2%) + Levonordefrin hydrochloride 0.06 mg)