Health and Aging Brain Study: Health Disparities Tau Positron Emission Tomography (PET) Scan Study

University of North Texas Health Science Center

Status: Unknown

Conditions: Alzheimer Disease

Treatments: Diagnostic Test: PI-2620 tracer for Tau PET scan

Study type: Observational

Funder types: Other

Identifiers

NCT05076331

2020-125

Details and patient eligibility

About

The purpose of this project is to study the aging brain among participants enrolled in the Health and Aging Brain Study: Health Disparities project . There are a number of things that can influence how people think as they age, including diabetes, depression, as well as our biology. In this study, the investigators seek to study the aging brain by using brain PET scans that create detailed pictures of the brain.

Full description

There are a number of things that can influence how we think as people age, including diabetes, depression, as well as our biology. In this study, the investigators are using PET scans with a tracer to create detailed pictures of the brain. This information will be used to help the investigators understand how the brain ages and in the future could be used to develop better diagnostics and treatments for Alzheimer's disease and memory loss in Mexican Americans, African Americans, and non-Hispanic whites. The goal of this study is to address this disparity by enrolling ethnically diverse participants in this study.

Enrollment: 3,000 estimated patients

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Enrolled in the Health and Aging Brain Study HD: Health Disparities project
2. Provided consent to re-contact
3. Willing and capable of undergoing PET scan of the head

Exclusion criteria

1. Inability to provide informed consent by self or by proxy.
2. Pregnant or breast feeding women*
3. History of alcoholism or drug dependency/abuse within the last 2 years before screening
4. Hypersensitivity to the active substance or to any of the following excipients is contraindicated: sodium dihydrogen phosphate, phosphoric acid, sodium ascorbate, ethanol (anhydrous), water for injection
5. Participants may not be in this study if they do not meet the safety criteria to undergo imaging procedures.

Trial design

3,000 participants in 1 patient group

Health and Aging Brain Study Cohort

Description:

Health and Aging Brain Study participants age 50 and older.

Treatment:

Diagnostic Test: PI-2620 tracer for Tau PET scan