Health Effects of Biodiesel Exhaust Exposure (BD100)

Umeå University

Status: Completed

Conditions: Vascular Endothelium

Treatments: Other: Forearm venous occlusion plethysmography study

Study type: Interventional

Funder types: Other

Identifiers

NCT01883466

UMU-12-14031

Details and patient eligibility

About

Urban air pollution is a major contributor to greenhouse gases and has been shown to increase cardiovascular mortality and morbidity. This century has seen a rebirth of biofuel marketing and research, with biodiesel emerging as one of the strongest contenders within international markets. The pursuit of alternative renewable fuels is incredibly complex and has powered research in agriculture, biotechnology, production, transportation, feedstocks, ecology and biomass manufacturing. In spite of this, health effects have been an almost completely overlooked aspect. The purpose of this study is to investigate whether 100% biodiesel exhaust exposure in healthy volunteers leads to cardiovascular and inflammatory responses. Further investigations into the chemical composition of biodiesel exhaust will also be performed.

Enrollment: 19 patients

Sex: Male

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Non-smoking, healthy male subjects. All subjects undergo a general health examination and are required to have normal clinical examination, ECG, blood tests and lung function.

Exclusion criteria

• Diabetes Mellitus
• Cardiovascular disease
• Asthma
• Respiratory infection within 2 weeks of the study
• Antioxidant- and/or vitamin supplementation within 1 week prior to, as well as during the course of the study. (incl vitamin C, Acetylcysteine)
• Smokers or regular snus usage

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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19 participants in 2 patient groups

Diesel exhaust exposure

Experimental group

Description:

1 hour exposure to dilute diesel exhaust (approximate particle matter concentration 300 mcg/m3) during intermittent exercise

Treatment:

Other: Forearm venous occlusion plethysmography study

Biodiesel exhaust exposure

Experimental group

Description:

1 hour exposure to dilute biodiesel exhaust (generated at same running conditions as diesel exhaust) during intermittent exercise

Treatment:

Other: Forearm venous occlusion plethysmography study