Health Effects of Milk Proteins in Elderly Subjects

University of Oslo

Status

Completed

Conditions

Healthy

Treatments

Dietary Supplement: Placebo

Dietary Supplement: Milk

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT02218333

2014/150/REK sør-øst C

Details and patient eligibility

About

The aim of the present study is to investigate effects of milk on body composition and muscle strength, inflammation, appetite, DNA damage/repair and PBMC whole genome transcriptomics in elderly subjects.

Enrollment

50 patients

Sex

All

Ages

70+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

≥ 70 years of age
reduced gait speed or
reduced "five times sit to stand test" or
reduced "timed step stair test " or
reduced grip strength
Stable body weight (last 3 months)
Mini Nutritional Assessment (MNA®) score ≥ 17
Mini-mental status (MMSE-NR) score: ≥ 24
Willing to participate according to the protocol

Exclusion criteria

Allergy/intolerance to milk/dairy products
High intake of milk and yoghurt
Physical active subjects
Known diabetes type I or II, or HbA1c ≥ 6,5%
Recent events of acute cardiovascular disease including stroke
Rapidly evolving diseases (active malignancy) or history of cancer (malignant tumors) last 3 years.
Severe inflammation-related diseases such as e.g. Crohn disease and arthritis
Chronic obstructive pulmonary disease
Increased blood pressure
High intake of alcohol
Reduced kidney function (GFR < 45 ml/min)
Increased hsCRP, ASAT, ALAT
Increased or suppressed TSH
Hormone therapy
Systemic use of glucocorticosteroids (anti-inflammatory steroid hormones). Use of spray and inhalator use is not exclusion.
Disability preventing physical tests
Using medications known to affect protein metabolism