Health Effects of Oat and Oat Bioactive in Human

Lund University

Status: Completed

Conditions: Postprandial Glucose Regulation

Treatments: Combination Product: Effects of Oat and Oat Components on Cardiometabolic risk variables

Study type: Interventional

Funder types: Other

Identifiers

NCT04542265

Protokoll 2018/8b

Details and patient eligibility

About

Aim of the study is to investigate health effects of oats and oat derived components, in human intervention studies, with the purpose to build new knowledge for development of cardiometabolic protective foods

Full description

The overall goal is to increase the knowledge which can be used for the development of food products with anti-diabetic properties, with the purpose to facilitate healthier food choices for people. More specifically the primary purpose of this project is to evaluate effects in healthy humans on cardiometabolic test markers of oat and oat based product. The new knowledge will form a base for the development of oat based food products with added health values.

Enrollment: 20 patients

Sex: All

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy adults
• BMI 18,5 - 28
• non smokers
• consuming a non-vegetarian diet that follows the Nordic guidances

Exclusion criteria

• Fasting blood glucose concentration >6.1 mmol/l
• Known cardio-metabolic disease (e.g. diabetes, hypertension, metabolic syndrome), gastro-intestinal disorders such as IBS (irritable bowel syndrome) that can interfere with the study results, food allergies. Further no antibiotics or probiotics should have been consumed within 4 weeks prior to and during the study

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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20 participants in 4 patient groups, including a placebo group

Oat product 1

Experimental group

Description:

The test portion is based on 50 gram available carbohydrates with added vegetable oil A. Test portion consumed as a breakfast meal prior to determinations of test variables in the morning.

Treatment:

Combination Product: Effects of Oat and Oat Components on Cardiometabolic risk variables

Oat product 2

Experimental group

Description:

The test portion is based on 50 gram available carbohydrates with added vegetable oil B. Test portion consumed as a breakfast meal prior to determinations of test variables in the morning.

Treatment:

Combination Product: Effects of Oat and Oat Components on Cardiometabolic risk variables

Oat product 3

Experimental group

Description:

The test portion is based on 50 gram available carbohydrates with added vegetable oil A + vegetable oil B. Test portion consumed as a breakfast meal prior to determinations of test variables in the morning.

Treatment:

Combination Product: Effects of Oat and Oat Components on Cardiometabolic risk variables

Control Product

Placebo Comparator group

Description:

The test portion is based on 50 gram available carbohydrates without added vegetable oil. Test portion consumed as a breakfast meal prior to determinations of test variables in the morning.

Treatment:

Combination Product: Effects of Oat and Oat Components on Cardiometabolic risk variables