Health Outcomes After Participating in Exercise (HOPE)

Wake Forest University (WFU)

Status: Completed

Conditions: Weight Loss; Aging; Obesity

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT03430115

IRB00043576

1R01AG056418-01 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

Aging is associated with significant declines in muscle mass, strength, and physical performance, all of which lead to disability, loss of independence, and adverse clinical outcomes. Obesity exacerbates these age-related declines in function and is associated with poorer clinical outcomes and quality of life. Weight loss can also worsen age-related loss of muscle mass and decrease bone mineral density. The overall goals of this study are to determine if the short-term functional benefits of intentional weight loss are sustained long-term, and to examine the long-term benefits and risks of weight loss.

Full description

Obesity exacerbates age-related declines in function and is associated with poorer clinical outcomes and quality of life. Although clinical trials conducted study teams show that diet-induced weight loss interventions in obese older adults, when combined with exercise, improve body composition and physical and metabolic function in the short-term, the overall safety and long-term benefits of intentional weight loss in older adults remain controversial. Weight loss can also worsen age-related loss of muscle mass and decrease bone mineral density. Because of these concerns, health care providers are reluctant to recommend weight loss in obese older adults. The goal is to determine whether weight loss-induced improvements in body composition and physical and metabolic function observed in short-term clinical trials persist over time is critical to inform geriatric obesity treatment.

Enrollment: 588 patients

Sex: All

Ages: 60+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All former participants from the five intervention trials who respond to our recruitment strategies will be scheduled for clinic/home visits or a phone interview.

Exclusion criteria

• None - all former participants from the five intervention trials are eligible

Trial design

588 participants in 4 patient groups

Weight loss plus exercise (WL+EX)

Description:

This group was randomized and previously assigned to weight loss plus exercise.

Exercise alone (EX)

Description:

This group was randomized and previously assigned to exercise alone.

Weight loss alone (WL)

Description:

This group was randomized and previously assigned to weight loss alone.

Control

Description:

This group was randomized and previously assigned to control.