Health Outcomes of Parents With Cystic Fibrosis (HOPeCF)

University of Pittsburgh

Status: Completed

Conditions: Parenthood Status; Cystic Fibrosis

Treatments: Other: Parental Status

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT05829694

KAZMER22A0 (Other Grant/Funding Number)

1R01HL161164-01A1 (U.S. NIH Grant/Contract)

STUDY22010135

Details and patient eligibility

About

This project will determine the health impact of parenthood on people with cystic fibrosis (CF). The study team will use retrospective data to provide relatively immediate evidence on parenthood's effect on pulmonary health.

Full description

This co-funded study sponsored by the National Institutes of Health and the CF Foundation (CFF) will seek to determine the health impact of parenthood on people with CF in the era of CF transmembrane conductance regulator (CFTR) modulators. To provide relatively immediate evidence on parenthood's effect on pulmonary health and the influence of the introduction and use of all available CFTR modulators, in Aim 1 the study team will assess changes in pre- vs. intra-parenthood percent predicted forced expiratory volume in 1 second (ppFEV1) in a retrospective longitudinal cohort study linking CFF patient registry (CFFPR) data with cross-sectional surveys collected from 249 new parents attending participating United States CF centers between 2012-2022. The study team will identify predictors and timing of lung function loss using 747 non-parents from participating centers as a comparison group and examine the impact of CFTR modulators on parental health.

Enrollment: 956 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Confirmed CF diagnosis with sweat or genotype analysis
• Participant in the CFFPR
• Became a first-time parent between the years 2012-2022 (exposure arm only)

Exclusion criteria

• Lung transplant prior to becoming a first-time parent (exposure arm) or prior to study period (control)
• Does not speak/read English or Spanish

Trial design

956 participants in 2 patient groups

Parents

Description:

Individuals diagnosed with cystic fibrosis who became a first-time parent between January 1, 2012 and December 31, 2022.

Treatment:

Other: Parental Status

Non-parents

Description:

Individuals diagnosed with cystic fibrosis who have never been a parent.