Health Parameters in Soccer Players and Sedentary Individuals After Consuming a Synbiotic

Catholic University of Murcia

Status: Completed

Conditions: Athlete; Sedentary Behavior

Treatments: Dietary Supplement: Placebo; Dietary Supplement: Synbiotic complement

Study type: Interventional

Funder types: Other

Identifiers

NCT04776772

CE031810

Details and patient eligibility

About

The main objective of this research was to carry out an experimental study, triple blind, on the possible immunophysiological effects of a nutritional supplement (Synbiotic, Gasteel Plus®, Heel España S.A.U.), containing a mixture of probiotic strains, such as Bifidobacterium lactis CBP-001010, Lactobacillus rhamnosus CNCM I-4036, Bifidobacterium longum ES1, as well as prebi-otic fructooligosaccharides, in both professional athletes and sedentary people. The effects on some inflammatory/immune (IL-1β, IL-10, and immunoglobulin A) and stress (epinephrine, nore-pinephrine, dopamine, serotonin, CRH, ACTH, and cortisol) biomarkers were evaluated, determined by flow cytometer and ELISA. The effects on metabolic profile and physical activity, as well as on various parameters that could affect physical and mental health, were also evaluated via the use of accelerometry and validated questionnaires.

Full description

This investigation was a triple blinded, randomized, placebo-controlled pilot study designed to identify the possible differing effects of the synbiotic Gasteel Plus® supplementation.

The participants were professional soccer players of the Second Division B of the Spanish League and sedentary students of the same sex and age range. Both study groups were randomly divided into two groups: a control group administered with placebo, and an experimental group administered with the synbiotic. Each participant was evaluated at baseline, as well as after the intervention which lasted one month. Only in the athletes group did the synbiotic intervention clearly improve objective physical activ-ity and sleep quality, as well as perceived general health, stress, and anxiety levels.

Enrollment: 27 patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Sedentary individuals: students with low levels of physical activity (≤ 150 minutes/week),
• Athletes: semi professional soccer players

Exclusion criteria

• Participants were prohibited from consuming probiotics, prebiotics or fermented products (yogurt or other foods)
• Presenting injury or illness

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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27 participants in 4 patient groups, including a placebo group

Soccer player placebo

Placebo Comparator group

Description:

Soccer player consuming placebo sticks filled with 300 mg excipient of maltodextrin

Treatment:

Dietary Supplement: Placebo

Soccer player synbiotic

Experimental group

Description:

Soccer players consuming a mixture of probiotic strains: Bifidobacterium lactis CBP-001010, Lactobacillus rhamno-sus CNCM I-4036, Bifidobacterium longum ES1 and fructooligosaccharides (200 mg) as a prebiotic

Treatment:

Dietary Supplement: Synbiotic complement

Sedentary individuals placebo

Placebo Comparator group

Description:

Sedentary individuals consuming placebo sticks filled with 300 mg excipient of maltodextrin

Treatment:

Dietary Supplement: Placebo

Sedentary individuals synbiotic

Experimental group

Description:

Sedentary individuals consuming a mixture of probiotic strains: Bifidobacterium lactis CBP-001010, Lactobacillus rhamno-sus CNCM I-4036, Bifidobacterium longum ES1 and fructooligosaccharides (200 mg) as a prebiotic

Treatment:

Dietary Supplement: Synbiotic complement