Heart and Blood Pressure Study: The Effect of Aortic Impedance on Myocardial Relaxation
Status
Conditions
Treatments
Details and patient eligibility
About
Does dilation of blood vessels (vasodilation), which decreases aortic stiffness, have a greater effect on heart myocardium relaxation (diastole) than vasodilation which affects mean pressure equally without improving aortic stiffness?
Full description
60 subjects, 30 with hypertension and 30 without will attend two visits to the GCRC. At each visit, pulsatile hemodynamics (by using tonometry-a non-invasive means to obtain arterial pressure tracings) and Doppler tissue imaging relaxation velocity (a measurement of myocardial relaxation obtained by echocardiography) data will be collected before and after administration of vasodilator medication. At the first visit, each patient will receive an oral dose of the vasodilator hydralazine (does not effect aortic stiffness), and at the second visit each patient will receive intravenous nesiritide (does effect aortic stiffness). The relationship between timing of the reflected pulse wave and myocardial relaxation velocity will be studied at baseline and following administration of each vasodilator to determine if changing aortic stiffness has an impact on myocardial relaxation.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Subjects over the age of 65
Exclusion criteria
- Have known or suspected coronary artery disease
- Have known or suspected left ventricular dysfunction
- Have significant valvular, infiltrative, pericardial, or congenital heart disease
- Have a resting systolic blood pressure < 100 mmHg
- Have had an adverse reaction to nesiritide or hydralazine
- Have a serum creatinine > 2 mg/dl at Visit 1
Trial design
Primary purpose
Allocation
Interventional model
Masking
Trial contacts and locations
Loading...
Data sourced from clinicaltrials.gov
Clinical trials
Research sites
Resources
Legal