Heart and Kidney Ketones Metabolism

Université de Sherbrooke

Status: Completed

Conditions: Healthy

Treatments: Dietary Supplement: Post-Prandial with exogenous ketone salt supplement; Dietary Supplement: Fasting with exogenous ketone salt supplement

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT04580823

2020-3441

Details and patient eligibility

About

Participants will undergo 3 Positron Emission Tomography (PET) scans in 3 different conditions :

1. Fasting without exogenous ketone salt
2. Fasting with exogenous ketone salt supplement
3. Post-Prandial with exogenous ketone salt supplement.

Full description

This study will help to quantify heart and kidney ketone uptake with or without an exogenous ketone salt with or without food intake in middle-aged adults. Participants will have 3 different PET scan to perform :

1. Fasting without exogenous ketone salt
2. Fasting with exogenous ketone salt supplement
3. Post-Prandial with exogenous ketone salt supplement.

Enrollment: 10 patients

Sex: All

Ages: 45 to 64 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Aged between 45 and 64
• Generally Healthy
• BMI between 18.5 and 27

Exclusion criteria

• All drugs taken on a daily basis
• Diabetes or pre-diabetes
• Digestive dysfunction
• Pregnancy or lactation
• Allergy to the supplement
• Participate in an intensive physical exercise training (more than three times a week)
• Being on a ketogenic diet or consumption of ketogenic supplement.
• More than 2 alcoholic beverages each day
• Any clinically significant anomaly in the blood profile
• Smoking
• Claustrophobia
• Being enrolled in another interventional research project or in a PET research project
• Unable to lie dorsally supine for at least 60 minutes

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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10 participants in 3 patient groups

Control

No Intervention group

Description:

Fasting without exogenous ketone salt supplement

Fasting with exogenous ketone salt supplement

Experimental group

Description:

Fasting with exogenous ketone salt supplement

Treatment:

Dietary Supplement: Fasting with exogenous ketone salt supplement

Post-Prandial with exogenous ketone salt supplement

Experimental group

Description:

Post-Prandial with exogenous ketone salt supplement

Treatment:

Dietary Supplement: Post-Prandial with exogenous ketone salt supplement