Heart Failure and Hemodynamic Stability During Anesthesia Induction

Umeå University

Status: Completed

Conditions: Diastolic Dysfunction; Anesthesia; Adverse Effect; Hemodynamic Instability; Venous; Return (Anomaly); Heart Failure

Treatments: Diagnostic Test: Preoperative transthoracic echocardiography; Other: Preoperative colloid fluid bolus (Gelofusine)

Study type: Interventional

Funder types: Other

Identifiers

NCT03576261

2016/361-31 III

Details and patient eligibility

About

The study aim is to investigate whether preoperative heart failure has impact on hemodynamic stability during anesthesia induction by target controlled infusion of anesthesia (TCI) in non-cardiac, non-morbidly obese surgery.

Full description

40 individuals are enrolled to the study after signed informed consent at the day of surgery. The study participants are randomized (non-blinded) to preoperative fluid therapy (preoperative colloid fluid bolus at 6 ml/kg LBW, Gelofusine™, Fresenius Kabi AB, Sweden) or control (no preoperative fluids) before standardized TCI- induction of anesthesia. No other intravenous fluids before anesthesia induction.

Preoperative screening of biventricular systolic and diastolic function of the heart and level of venous return is implemented by transthoracic echocardiography approximately one hour before preoperative fluid therapy and anesthesia induction.

Enrollment: 44 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age over 18 years
• body mass index ≤ 35 kg/m2
• electively scheduled for breast cancer surgery, endocrinologic surgery (thyroid, parathyroid) and general abdominal surgery

Exclusion criteria

• instable angina pectoris
• severe bronchial asthma
• severe COPD
• dementia
• severe heart valve disease
• severe renal failure
• body mass index > 35 kg/m2

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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44 participants in 2 patient groups

Preoperative echo + fluids

Experimental group

Description:

20 individuals investigated by preoperative transthoracic echocardiography. Preoperative colloid fluid bolus (Gelofusine, Fresenius Kabi AB, Sweden) 6 ml/kg lean body weight, is infused intravenously immediately before anesthesia induction.

Treatment:

Other: Preoperative colloid fluid bolus (Gelofusine)

Diagnostic Test: Preoperative transthoracic echocardiography

Preoperative echo, control

Active Comparator group

Description:

20 individuals investigated by preoperative transthoracic echocardiography. No intravenous fluids are infused before anesthesia induction.

Treatment:

Diagnostic Test: Preoperative transthoracic echocardiography