Heart Rate and Initial Presentation of Cardiovascular Diseases (Caliber)

University College London (UCL)

Status: Unknown

Conditions: Coronary Heart Disease NOS; Ischemic Stroke; Unstable Angina; Stroke; Transient Ischemic Attack; Myocardial Infarction; Heart Failure; Subarachnoid Haemorrhage; Peripheral Arterial Disease; Cardiac Arrest, Sudden Cardiac Death; Intracerebral Haemorrhage; Unheralded Coronary Death; Stable Angina Pectoris; Abdominal Aortic Aneurysm

Study type: Observational

Funder types: Other

Identifiers

NCT01947361

12_153R_IP10

RP-PG-0407-10314 (Other Grant/Funding Number)

Details and patient eligibility

About

Study of heterogeneity in associations between heart rate and the initial presentation of 12 cardiovascular diseases.

Full description

This study is part of the CALIBER (Cardiovascular disease research using linked bespoke studies and electronic records) programme funded over 5 years from the NIHR and Wellcome Trust. The central theme of the CALIBER research is linkage of the Myocardial Ischaemia National Audit Project (MINAP) with primary care (GPRD) and other resources. The overarching aim of CALIBER is to better understand the aetiology and prognosis of specific coronary phenotypes across a range of causal domains, particularly where electronic records provide a contribution beyond traditional studies. CALIBER has received both Ethics approval (ref 09/H0810/16) and ECC approval (ref ECC 2-06(b)/2009 CALIBER dataset).

Enrollment: 1,961,286 patients

Sex: All

Ages: 30+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• One year prior to study entry (up-to-standard follow-up, CPRD quality research standard).
• > 30 years old
• have at least a recorded heart rate measurement during the study period

Exclusion criteria

• Evidence of prior atherosclerotic or cardiac disease