Heart Rate, Baroreflex Sensitivity and Cardiovascular Morbidity and Mortality in the Population (PPSIII)

Institut National de la Santé Et de la Recherche Médicale, France

Status: Active, not recruiting

Conditions: Community Based Study; Sudden Death; Blood Pressure; Cardiovascular Disease

Treatments: Other: Spider flash ECG, high-precision carotid echo-tracking, step test

Study type: Observational

Funder types: Other

Identifiers

NCT00741728

2007-A01386-47 (Registry Identifier)

C07-39

Details and patient eligibility

About

The aim of the present Paris Prospective Study III (PPS3) is (1) to assess the determinants of the regulation of heart rate and blood pressure variations and carotid properties (under different physiologic stimulations) and (2) to evaluate the respective contribution of heart rate, blood pressure variations and carotid properties to cardiovascular morbidity and mortality including sudden death during 10 years at least in healthy considered subjects.

Full description

Overall, 10 157 men and women have been recruited during May 2008 and June 2012 for an extensive clinical examination including a 2h holter electrocardiography (ECG), a carotid doppler echo tracking, a step test, as well as blood and DNA collections. Since then, the cardiovascular morbidity and mortality of the participants is being followed up for 10 years at least and will continue up to 2032.

Enrollment: 10,157 patients

Sex: All

Ages: 50 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 50-75 years, French speaking, given consent for genetic analysis,
• written consent for participating in the study

Exclusion criteria

• <50 years and >75 years,
• no French speaking,
• current pregnancy,
• chronic severe disease,
• disagreement for genetic analysis,
• step test considered as non possible or non advisable by medical decision.

Trial design

10,157 participants in 1 patient group

general population

Description:

Observational study of 10157 adult men and women from the general population who benefited from a free extensive health check up in Paris, France

Treatment:

Other: Spider flash ECG, high-precision carotid echo-tracking, step test