Heart Rate Variability of Patients With Bipolar Disorder in Subsyndromal Depressive Phase

Asan Medical Center

Status: Completed

Conditions: Subsyndromal Depressive Phase; Bipolar Disorder; Heart Rate Variability

Study type: Observational

Funder types: Other

Identifiers

NCT01455038

A090116

Details and patient eligibility

About

The purposes of this study were: (1) to compare heart rate variability between bipolar patients in subsyndromal depressive phase and healthy controls (2) to evaluate the relation between the severity of subsyndromal depressive symptoms and reduced heart rate variability.

Enrollment: 92 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Bipolar group:

   • DSM-IV bipolar disorder
   • Montgomery-Åsberg depression rating scale (MADRS) score for last one month : ≤ 10
   • Clinical Global Impression severity (CGI-S) for last one month : ≤ 3

2. Healthy controls group: Subjects had no history of psychiatric disorder and had no psychiatric symptom when interviewed by a board-certified psychiatrist.

Exclusion criteria

• Psychiatric disorder except bipolar disorder
• Neurological symptoms or signs
• History of head trauma
• History of cardiovascular diseases
• Any medication except psychiatric medication.

Trial design

92 participants in 2 patient groups

Control group

Description:

Healthy controls had no history of psychiatric disorder and had no psychiatric symptom when interviewed by a board-certified psychiatrist.

Bipolar group

Description:

individual patient as being in subsyndromal depressive phase when the patient had a Montgomery-Åsberg depression rating scale score of 10 or less and Clinical Global Impression severity of 3 or less for last one month.