Heart Rate Variability Under Propofol and Sevoflurane

Hôpital Armand Trousseau

Status: Completed

Conditions: General Anesthesia

Treatments: Drug: Sevoflurane; Drug: Propofol; Drug: Remifentanil

Study type: Interventional

Funder types: Other

Identifiers

NCT03098875

HRV Propofol Sevoflurane

Details and patient eligibility

About

Patients were randomized into 2 groups according to the anesthetic, propofol or sevoflurane. Induction and maintenance were standardized, and after the end of surgery, two steady-state recordings were performed at BIS 25 and BIS 55. Bispectral Index and ECG were continuously recorded and cardiac autonomic nervous activity was investigated using spectral analysis of RR Interval variability

Enrollment: 40 patients

Sex: All

Ages: 13 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA risk classification 1 or 2,
• scheduled for middle ear surgery, or cardiovascular ANS activity.

Exclusion criteria

• preoperative medications that interfere with the autonomic nervous system
• preoperative medications that interfere with the central nervous system

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups

Sevoflurane

Active Comparator group

Description:

General anesthesia using sevoflurane as a hypnotic agent, and remifentanil as an analgesic. Two steady state periods of 10 minutes each, one with a steady bispectral index at 25 +/- 5, the other with a steady bispectral index at 55 +/- 5. Continuous recording of heart rate during the last minute of each steady-state. Off-line spectral analysis of heart rate variability.

Treatment:

Drug: Remifentanil

Drug: Sevoflurane

Propofol

Active Comparator group

Description:

General anesthesia using propofol as a hypnotic agent, and remifentanil as an analgesic. Two steady state periods of 10 minutes each, one with a steady bispectral index at 25 +/- 5, the other with a steady bispectral index at 55 +/- 5. Continuous recording of heart rate during the last minute of each steady-state. Off-line spectral analysis of heart rate variability.

Treatment:

Drug: Remifentanil

Drug: Propofol