Heat Shock Proteins: a Pathogenic Driver and Potential Therapeutic Target in Acute Pancreatitis (DIAGNON)

Vilnius University

Status: Unknown

Conditions: Acute Pancreatitis

Treatments: Diagnostic Test: CT Scan Day 5-7

Study type: Observational

Funder types: Other

Identifiers

NCT03634787

158200-17-941-455

Details and patient eligibility

About

To investigate the role of Heat Shock Proteins in the mechanism of acute severe pancreatitis. In addition to test the potential treatment target of acute pancreatitis.

All patients who present with clinical symptoms of acute pancreatitis are evaluated for the enrollment of the study.

Full description

All patients with acute pancreatitis are evaluated according to modified Atlanta classification acute pancreatitis severity scores.

Blood serum, urine and DNA samples are collected from all patients presented on admission, after 24 hours, 48 hours, 72 hours.

CT is performed in al patients to evaluate necrosis of pancreas Day 5-7 since hospital admission. If necrosis is not present follow-up is stopped.

Enrollment: 280 estimated patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• no prior diagnosis of acute pancreatitis
• admission to the hospital within 2 days since the clinical symptoms
• confirmed diagnosis of acute pancreatitis

Exclusion criteria

• chronic pancreatitis
• pancreatic cancer

Trial design

280 participants in 2 patient groups

Acute pancreatitis

Description:

First time acute pancreatitis. No later than 2 days since the clinical symptoms started.

Treatment:

Diagnostic Test: CT Scan Day 5-7

Healthy

Description:

No major systemic illness