Heated Humidified Oxygen Compared to Dry Oxygen Therapy in Children With Bronchiolitis

UCSF Benioff Children's Hospital Oakland

Status: Completed

Conditions: Bronchiolitis; Hypoxemia

Treatments: Device: Heated and humidified oxygen

Study type: Interventional

Funder types: Other

Identifiers

NCT02094664

2013-066

Details and patient eligibility

About

The purpose of this study is to compare heat and humidified oxygen with cold and dry oxygen in children with bronchiolitis.

The hypotheses are that heating and humidifying inspired low flow supplemental oxygen will optimize mucociliary function thereby, 1) improve oxygenation, 2) decrease work of breathing, and 3) decrease length of hospital stay.

Full description

Bronchiolitis is the leading cause of acute respiratory illness and hospitalization in infants and young children. The mainstay of treatment is supportive care, which includes frequent nasal suctioning, intravenous fluid hydration, and supplemental oxygen for hypoxemia.

The airways normally heat and humidify inspired ambient air to core temperature amd 100% relative humidity at the carina. This environment, at core temperature, allows for optimal mucociliary clearance. Supplemental oxygen delivered via wall source is cold and dry, and does not reach core temperature and 100% humidity until some point distal to the carina, past the main bronchi. This presses on the lower respiratory tract to assist in heat and moisture exchange and thus decrease ciliary function. This, in combination with bronchiolitis, can impair mucociliary clearance.

Specific aim 1: Determine the effect of heated and humidified oxygen therapy on clinical improvement in children with bronchiolitis, based on Respiratory Distress Assessment Instrument (RDAI) and respiratory rate (RR).

Specific aim 2: Determine the effect of heated and humidified oxygen therapy on length of hospital stay and duration of supplemental oxygen requirement in children with bronchiolitis.

Enrollment: 32 patients

Sex: All

Ages: Under 24 months old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Ages ≤24 months of age
• Physician diagnosed bronchiolitis
• Admitted to pediatric floor
• Supplemental oxygen requirement, <4 L/min, for hypoxemia, oxygen saturation <92% in room air

Exclusion criteria

• Prematurity, born <37 weeks gestational age
• Admitted to pediatric intensive care unit for medical indication
• Requirement of heated, humidified high flow system
• Chronic lung disease (such as bronchopulmonary dysplasia, cystic fibrosis, primary ciliary dyskinesia, tracheostomy status, baseline oxygen requirement)
• Neuromuscular disorders
• Chromosomal defects
• Metabolic disorders
• Immunodeficiency
• Unrepaired cardiac abnormalities

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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32 participants in 2 patient groups

Standard oxygen via nasal cannula

No Intervention group

Description:

Standard therapy

Heated and humidified oxygen

Active Comparator group

Description:

Heated and humified oxygen

Treatment:

Device: Heated and humidified oxygen