Hedonic Perception and Brain Activity Response to Meal

Vall d'Hebron University Hospital (HUVH)

Status: Completed

Conditions: Dyspepsia

Treatments: Device: Functional brain MRI; Dietary Supplement: A warm ham and cheese sandwich and a 200 ml fruit juice

Study type: Interventional

Funder types: Other

Identifiers

NCT02592239

PR(AG)214/2012 Addendum

Details and patient eligibility

About

The purpose of this study is to determine the relationship between brain activity and the perception of subjective hedonic sensations in response to a meal using functional MRI.

Full description

Functional MRI brain imaging will be performed in patients with functional dyspepsia and healthy controls in basal conditions and after a palatable test meal. During the study, the cognitive response and the hedonic dimension will be measured using 10 score scales.

Enrollment: 80 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Age between 18 and 80 yrs
2. Body mass index between 18-30 Kg/m2
3. Right-handed

Exclusion criteria

1. Subjects with clinical history of eating-disorders
2. Subjects with clinical history of significant head-trauma
3. Subjects with known serious illness: clinically significant cardiac, vascular, liver, pulmonary, or psychiatric disorders (as evaluated by the Investigator).
4. Subjects with a known history of alcohol or drug abuse in the previous 6 months.
5. Subjects using medications with SNS effects that cannot be discontinued, such as: antidepressants, pregabalin, gabapentin.
6. Women that are pregnant or that are breast-feeding.
7. Claustrophobia

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

80 participants in 2 patient groups

Patients

Experimental group

Description:

Functional dyspepsia patients will be studied using functional brain MRI before and after receiving a test meal. Cognitive and hedonic response will be evaluated using 10 score scales.

Treatment:

Dietary Supplement: A warm ham and cheese sandwich and a 200 ml fruit juice

Device: Functional brain MRI

Controls

Experimental group

Description:

Healthy subjects recruited by public advertisement will be studied using functional brain MRI before and after receiving a test meal. Cognitive and hedonic response will be evaluated using 10 score scales.

Treatment:

Dietary Supplement: A warm ham and cheese sandwich and a 200 ml fruit juice

Device: Functional brain MRI