Helical CT, PET/CT, MRI, and CBCT Alone or in Combination in Predicting Jaw Invasion in Patients With Oral Cancer

Sidney Kimmel Cancer Center at Thomas Jefferson University

Status

Terminated

Conditions

Oral Cavity Squamous Cell Carcinoma

Treatments

Device: Computed Tomography

Device: Positron Emission Tomography and Computed Tomography Scan

Procedure: Histopathologic Examination

Procedure: Therapeutic Conventional Surgery

Device: Cone-Beam Computed Tomography

Device: Magnetic Resonance Imaging

Study type

Observational

Funder types

Other

Identifiers

NCT03053960

15D.468

Details and patient eligibility

About

This clinical trial studies how well helical computed tomography (CT), positron emission tomography (PET)/CT, magnetic resonance imaging (MRI), and cone beam computed tomography (CBCT) work alone or in combination in predicting whether tumor cells have spread to the jaw bone (jaw invasion) in patients with oral cancer. Imaging, such as helical CT, PET/CT, MRI, and CBCT, may help find out how far cancer has spread. Accurate prediction of the presence or absence of jaw invasion may help create a better surgical treatment plan for patients with oral cancer.

Full description

PRIMARY OBJECTIVES:

I. To determine which imaging modality or combination of imaging methods, in conjunction with clinical and histological examination, will most accurately predict the presence or absence of invasion of the mandible or maxilla by intraoral squamous cell carcinoma (SCC).

SECONDARY OBJECTIVES:

I. To compare the histopathologic findings to the radiologic findings.

Enrollment

8 patients

Sex

All

Ages

18 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Diagnosis of squamous cell carcinoma of the oral cavity
Able to read and sign and informed consent

Exclusion criteria

Prior mandibular surgery
Primary intraosseous carcinoma
Prior history of radiation to the mandible
Obvious finding of clinical invasion of the mandible

Trial design

8 participants in 1 patient group

Diagnostic (helical CT, PET/CT, MRI, CBCT)

Description:

Patients undergo helical (Computed Tomography) CT,(Positron Emission Tomography and Computed Tomography) PET/CT, (Magnetic Resonance Imaging) MRI, and (Cone-Beam Computed Tomography) CBCT scans. Patients also undergo therapeutic conventional surgical resection of tumor.