Heliox and Posture in Patients With Asthma

Universidade Federal de Pernambuco

Status: Completed

Conditions: Acute Asthma

Treatments: Other: OXYGEN + POSTURE; Other: HELIOX+POSTURE; Other: OXYGEN; Other: HELIOX

Study type: Interventional

Funder types: Other

Identifiers

NCT00922350

2525

Details and patient eligibility

About

The purpose of this study is to verify that nebulization with bronchodilators associated with heliox gas (helium + oxygen) and the posture of a leaning forward truck is effective in patients with an asthma attack.

Full description

When associated with inhaled bronchodilators, the heliox, a mixture of helium and oxygen in obstructive lung diseases with asthma, reduces the turbulence of airflow despite high rates, due to its low density.

Although the first report of the use of heliox in the treatment of asthma dating to 1935, few controlled studies are available clarify the impact of the use of heliox in hospital admission of patients with acute asthma attacks refractory to standard treatment.

The severe airflow obstruction, observed in cases of acute asthma, also leads to lung hyperinflation that favors the increase of respiratory work by increasing the load for the inspiratory muscles by placing them at a mechanical disadvantage.

Various body positions were studied relating them to muscle activity with mechanical disadvantage. These studies suggest that the influence posture acts mainly in the position of the diaphragm, thus, increasing the stress related to other muscles such as the abdominals and the effect of gravity on these.

This study aims to: assess the efficiency of the positioning body associated with nebulization with bronchodilators carried by heliox during acute severe asthma in adults, using as the primary outcomes FEV1, FVC and PEF and secondary outcomes as the Borg scale, inspiratory capacity, RR, HR and SpO2.

Enrollment: 59 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• reversibility of bronchial obstruction after administration of bronchodilator drugs for at least 10% in FEV1
• a clinical diagnosis of acute severe asthma
• a history of asthma over 1 year
• duration of the crisis of current asthma lasting less than seven days

Exclusion criteria

• were unable to understand or perform the spirometric maneuver
• smoking (within the last 3 years associated with a higher consumption of 100 cigarettes/year)
• other pulmonary comorbidities
• lower to upper airways
• heart failure
• heart rate greater than 150 bpm
• systolic pressure below 90 mmHg or greater than 150 MHG
• pregnancy
• inability to stay inline with the trunk forward

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Double Blind

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59 participants in 4 patient groups

heliox

Experimental group

Description:

The patients in this group underwent nebulization with heliox carried by the trunk erect

Treatment:

Other: HELIOX

heliox+posture

Experimental group

Description:

The patients in this group carried out the mist carried by heliox and the trunk tilted forward

Treatment:

Other: HELIOX+POSTURE

oxygen+posture

Experimental group

Description:

The patients in this group carried out the mist carried by oxygen and the trunk tilted forward

Treatment:

Other: OXYGEN + POSTURE

oxygen

Active Comparator group

Description:

The patients in this group carried out the mist carried by the oxygen and the trunk upright

Treatment:

Other: OXYGEN