Helium Oxygen Mixture in the Treatment of Meconium Aspiration Syndrome

Ma Juan

Status: Completed

Conditions: Neonatal Meconium Aspiration

Treatments: Device: helium oxygen mixture

Study type: Interventional

Funder types: Other

Identifiers

NCT02620891

MJuan

Details and patient eligibility

About

Helium-oxygen mixture(heliox) was suggested to be beneficial in meconium aspiration syndrome in previous studies，but the evidence was limited．The aim of the study was to assess the effectiveness of synchronize intermittent mandatory ventilation (SIMV) with heliox (70% helium and 30% oxygen) on length of ventilation(LoV) and cardiopulmonary protection in meconium aspiration syndrome.

Enrollment: 60 estimated patients

Sex: All

Ages: 37 to 40 weeks old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Subject has the diagnosis of neonatal meconium aspiration syndrome
• Subject has Synchronous instruction ventilation

Exclusion criteria

• History of congenital or hereditary disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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60 participants in 2 patient groups

experimental group

Active Comparator group

Description:

Using helium oxygen mixture

Treatment:

Device: helium oxygen mixture

matched group

No Intervention group

Description:

Using air oxygen mixture