Helium:Oxygen Noninvasive Positive Pressure Ventilation in Patients Exposed to Sulfur Mustard

Baqiyatallah Medical Sciences University

Status and phase: Completed; Phase 3; Phase 2

Conditions: Chronic Bronchitis; Bronchiolitis

Treatments: Drug: helium:oxygen mixture

Study type: Interventional

Funder types: Other

Identifiers

NCT00642447

B12406

Details and patient eligibility

About

to assess the effect of Heliox with Noninvasive positive pressure ventilation to decrease dyspnea and improve physiologic and respiratory measures in patients with a previous exposure to Sulfur Mustard gas.

Sex: Male

Ages: 38 to 59 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• exposure to sulfur mustard
• worsening dyspnea during the last 10 days
• respiratory rate of >25/min
• arterial pH<7.35
• PaCO2 of >50 mmHg
• PaO2 of <50 mmHg

Exclusion criteria

• recent pneumothorax (<1 month)
• severe respiratory failure or hemodynamic instability with forthcoming intubation
• FIO2 of <0.4
• impaired consciousness or absence of patient cooperation
• facial lesions precluding NIPPV

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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23 participants in 1 patient group

1

Experimental group

Treatment:

Drug: helium:oxygen mixture