Helsinki Ultra-acute Stroke Biomarker Study

Helsinki University Central Hospital (HUCH)

Status: Completed

Conditions: Acute Stroke

Study type: Observational

Funder types: Other

Identifiers

NCT02145663

MNEURT ISCHEMIC STROKE 813 (Other Identifier)

HUSBS2013

Details and patient eligibility

About

The aim of this study is to establish diagnostic and predictive biomarkers for patients with suspected acute stroke, that are transported by EMS as candidates for thrombolytic treatment. The study focuses on the ultra acute phase, <4.5 hours from symptom onset, including the prehospital setting. Analyses will include known biomarkers (e.g. GFAP, NR2 peptide) and a discovery phase for novel markers. Patient outcome will be evaluated at 3 month using the modified Rankin Scale (mRS).

Enrollment: 1,046 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Acute stroke suspected by EMS personnel
• Transport to tertiary hospital as possible candidate for thrombolytic treatment of ischemic stroke
• Age ≥18
• Successful prehospital blood sampling by EMS personnel

Exclusion criteria

• Unsuccessful prehospital blood sampling by EMS personnel