Hematologic Ratios in Postoperative Acute Kidney Injury

Cincinnati Children's Hospital Medical Center

Status: Withdrawn

Conditions: Acute Kidney Injury

Treatments: Procedure: Cardiac Surgery with Cardiopulmonary Bypass

Study type: Observational

Funder types: Other

Identifiers

NCT03658148

CIN001-AKI Hematologic Ratios

Details and patient eligibility

About

Acute kidney injury (AKI) is a common complication after surgery for congenital heart disease and is associated with significant morbidity and mortality. To-date, no biomarker has been universally implemented for predicting AKI in neonates after cardiac surgery. In this study, the use of hematological ratios will be evaluated for predicting AKI and postoperative outcomes in this patient cohort.

Full description

In adults, hematological ratios which can be calculated from a routinely ordered complete blood count with differential, such as the neutrophil/lymphocyte ratio, have been demonstrated to be correlated with acute kidney injury (AKI) and other clinical outcomes after cardiovascular surgery. In this retrospective observational study, the association between hematological ratios (neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, neutrophil/lymphocyte*platelet ratio, monocyte/lymphocyte ratio, and plateletcrit) and postoperative AKI, morbidity (length of ICU stay, hospital stay, mechanical ventilation, vasoactive infusion-free days, etc.) and mortality will be evaluated in neonates who underwent cardiac surgery with cardiopulmonary bypass.

Sex: All

Ages: Under 31 days old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Neonates (≤31 days) who underwent cardiac surgery with cardiopulmonary bypass for congenital heart disease.

Exclusion criteria

• Patients with missing relevant preoperative or postoperative data points
• Patients with previous palliation or reoperation,
• Thymus hypo/aplasia (DiGeorge Syndrome, Ataxia-telangiectasia, or Nezelof syndrome),
• Primary immunodeficiency,
• Episode of cardiac arrest within 1 week before surgery,
• Signs or history of preoperative renal impairment or AKI (KDIGO Stage ≥1 observed on preoperative labs),
• Hypothyroidism,
• Patients with a history of infection within a week prior to surgery or antibiotics administered within the first 3 days after surgery (except for postoperative antibiotics).

Trial design

0 participants in 1 patient group

Study Group

Description:

Neonates (≤31 days) who underwent cardiac surgery with cardiopulmonary bypass for congenital heart disease (CHD) between 2008-2017.

Treatment:

Procedure: Cardiac Surgery with Cardiopulmonary Bypass