HEmiplegia Arrhythmia Retrospective Trial (HEART)

Civil Hospices of Lyon

Status: Completed

Conditions: Alternating Hemiplegia of Childhood

Treatments: Other: Recording of clinical parameters and electrocardiogram parameters

Study type: Observational

Funder types: Other

Identifiers

NCT04944927

69HCL21_0493

Details and patient eligibility

About

Alternating Hemiplegia of Childhood (AHC) is a rare and severe disease that is in need of effective, and hopefully even curative, therapies. Afflicted patients suffer from severe paralyzing crises, often excruciatingly painful muscle spasms, severe often life threatening epileptic seizures, frequently severe developmental and psychiatric/psychological disabilities and other comorbidities, such as cardiac disturbances. Recent data indicate that AHC genotype is in relation to cardiac repolarization troubles and to cardiac arrhythmias. The primary hypothesis to explore is that there is an association between genotype and cardiac phenotype in AHC.

Enrollment: 20 patients

Sex: All

Ages: 12+ months old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients that meet the clinical diagnostic criteria (Aicardi et al, 1995) for typical alternating hemiplegia with or without identified mutations in ATP1A3.
• At least one ECG study is required.
• Patients ages yearand more

Exclusion criteria

• Informed consent or assent not obtainable
• ATP1A3 testing not performed
• No ECG studies are available

Trial design

20 participants in 1 patient group

Patients with Alternating Hemiplegia of Childhood

Description:

Patients that meet the clinical diagnostic criteria (Aicardi et al, 1995) for typical alternating hemiplegia with or without identified mutations in ATP1A3. At least one prolonged ECG study available is required.

Treatment:

Other: Recording of clinical parameters and electrocardiogram parameters